Author: Gao Siyang, Shengjing Hospital affiliated to China Medical University
Pregnancy is a special period in a woman’s life. It not only faces the role of the role, but also pays special attention to diet and medication.So, I believe that you would like to ask if taking drugs during pregnancy must have a teratogenic effect on the fetus? The following pharmacists will answer it for you.
The influence of drugs on the fetus is not only related to the pregnancy stage of the fetus, but also related to the toxicity of the drug’s pregnancy and the dosage of the drug.
Both husbands and wives should try to avoid contact with teratogenic dangerous drugs before pregnancy, and even men’s medication, because drugs have the possibility of deforming the normal development of the embryo through sperm or semen.
Egg fertilized to fertilized eggs in the period before the endometrium.Embryo development is in the early stage of cell proliferation, and the effect of drugs on embryos is "full" or "none"."All" is manifested in the early death of the embryo; "none" is that the embryo continues to develop without abnormalities.Because the cells have not been differentiated at this time, if the drug is severely damaged, it often causes early abortion.
Within 12 weeks of pregnancy, the most sensitive period of drug terators. During this period, it was an organ formation period, so the medication should be particularly careful.
The organs of the fetus have been divided, and the teratogenic effect of drugs has weakened significantly, but for some drugs that have not been completely differentiated, certain drugs may also affect it, such as fetal teeth and reproductive systems.The nervous system can always exist due to the continuous division of development throughout the pregnancy.
If analgesic during the birth process, it is not advisable to choose octopenic analgesic drugs with strong respiratory inhibitory effects.影响 哌 is commonly used as a drug for childbirth because it does not affect the contraction of the uterine and does not delay the birth process.It is better to give birth within 1 hour or 4 hours after medication.
Pharmaceutical pregnancy toxicity classification:
The toxicity of drug pregnancy is different from the toxic and side effects of the drug, but according to the Food and Drug Administration (FDA) of the US Food and Drug Administration (FDA), according to the teratogenic condition of the drug to the fetus, the drug to benefit the treatment of pregnant women and the potential danger of the fetus will be evaluated.It is divided into five levels: A, B, C, D, and X.
Class A: Safety for pregnant women; Class B: Relatively safe for pregnant women; Class C: Be careful after weighing the advantages and disadvantages of pregnant women; Class D: It must be used when pregnant women must be favorable; level X: absolutely prohibited use;
Class A: After clinical control research, no drugs have a harmful effect on the fetus in the early pregnancy and middle and late stages.Including: vitamin A, vitamin B2, vitamin C, vitamin D, vitamin E, left paranar sodium, folic acid.
Class B: After research by animal experiments, no harm to the fetus and no clinical control experiments.Or the animal research experiments have side effects, but these side effects have not been confirmed in clinical research.
Class C: Animal experiments show that there is adverse effects on the fetus and no clinical control experiments.Or there are no animal and clinical research.
Class D: Clinical control or observation experiments have sufficient evidence to prove that it is harmful to the fetus.But treatment benefits may exceed potential hazards.
Grade X: Various experiments confirmed that the fetus would cause abnormalities, banned for women who are pregnant or about to be pregnant.
The above category is the harmfulness of the fetus for the fetus during the common dosage of the drug. The drug is different from the dosage of the drug. When a large dose of Class A drugs is large, the harm of Class C or X drugs may be generated.This category system is to evaluate the benefits of the treatment of drugs to the treatment of pregnant women and the potential danger of the fetus, and does not reflect the real toxicity of the drug.
Principles of medication during pregnancy:
1. Drugs for pregnancy need to be clearly indicated. A drug with a high -efficiency and high safety should be used to avoid new drugs with unknown use of pregnancy safety.
2. You need to clearly understand the number of pregnancy weeks when taking medicine. You can use it as little as possible during pregnancy, especially in the first three months of pregnancy. When you need to use it, you should use effective and safer drugs for the fetus.
3. Strictly grasp the dosage and stop the medicine in time.
4. Single medicine effectively avoids combined medication.
5. If the pregnant woman has used some possible teratogenic drugs, the treatment plan should be comprehensively considered according to factors such as the dose and the pregnancy month during the medication.
1. In childcare women, remember not to ignore whether they are conceived, so as not to use drugs that affect pregnancy during pregnancy.
2. When suffering from diseases during pregnancy, the diagnosis should be clearly diagnosed and rational treatment, including the treatment of drugs, and considers whether to terminate the pregnancy according to the degree of the disease.Do not delay the medication due to the influence of drugs on the fetus, leading to deterioration, or even endangering the life of the mother.
Avoid taking medicine during pregnancy, you should buy and use medicine under the guidance of the physician and pharmacist.
Review expert: He Xiaojing, Shengjing Hospital affiliated to China Medical University
The above is the original work of the "Drug Safety Cooperation Alliance" volunteer. If you reprint, please indicate the author and source!
[Medicine Shield Public Welfare] Public welfare organizations jointly sponsored and established with the China Society of Pharmaceuticals, Chinese Pharmaceuticals, Chinese Medical Association, and the Chinese Medical Association, PSM Media Shield Public Welfare (Public Number: PSMCHINA), Guanghui Resources, condense strength, and promote public medication for medication.Safety.